Interest in the abnormal metabolism displayed by cancer cells has been reawakened by the discovery of oncogenic mutations in metabolic enzymes, and also by devices that screen metabolism in life cells. Existing and also emerging therapies aim to target this abnormal line in various ways.

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William G. Kaelin Jr is in ~ the Howard Hughes clinical Institute, and also at the Dana-Farber Cancer Institute and also Brigham and Women"s Hospital, Harvard clinical School, Boston, Massachusetts 02115, USA. William_kaelin;

William G. Kaelin Jr

Craig B. Thompson is at the Abramson Cancer Center and Abramson household Cancer study Institute, college of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. Craig

Competing interests

W.G.K. Is a consultant to FibroGen Pharmaceuticals and to Agios Pharmaceuticals. C.B.T. Is a founder and chair the the advisory board of Agios Pharmaceuticals.

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Kaelin, W., Thompson, C. Hints from cabinet metabolism. 465, 562–564 (2010). Https://

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Published: 02 June 2010

Issue Date: 03 June 2010

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