Erythropoietin is a hormone, produced mainly in the kidneys, i m sorry stimulates the production and also maintenance the red blood cells.

Alternative names for erythropoietin

Erythropoietin is generally referred to together EPO. It is also called haematopoietin or haemopoietin, but these names room rarely provided today.

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What is erythropoietin?

Erythropoietin (EPO) is a hormone the is created predominantly by specialised cells dubbed interstitial cells in the kidney. Once it is made, it acts upon red blood cells to protect them versus destruction. In ~ the very same time it stimulates stem cells of the bone marrow to rise the production of red blood cells.


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Erythropoeitin experimentation in sport. Blood sample being tested because that the existence of the performance-enhancing hormone erythropoeitin.


Although the an accurate mechanisms that regulate the production of erythropoietin space poorly understood, the is well known that specialised cells in the kidney are capable of detecting and responding to short levels of oxygen (hypoxaemia) through raised production that erythropoietin. Once there is enough oxygen in the blood circulation, the production of erythropoietin is reduced, however when oxygen levels go down, the manufacturing of erythropoietin go up. This is one adaptive mechanism since it facilitates the production of an ext red blood cells to transport more oxygen about the body, hence raising oxygen level in the tissues. Because that example, when relocating in come a high altitude the air press drops and this can cause hypoxia that stimulates boost in erythropoietin production. In low oxygen states, people risk emerging hypoxia - oxygen deprivation. Hypoxia can likewise occur when there is poor ventilation that the lungs such together occurs in chronic lung disease, emphysema and also in cardiovascular disease. The manufacturing of erythropoietin is lessened in details conditions such as kidney failure, chronic diseases like HIV/AIDS, and particular cancers and in chronic inflammatory conditions like rheumatoid arthritis.

What wake up if I have actually too lot erythropoietin?

Excess erythropoietin outcomes from chronic exposure to short oxygen level or from rare tumours that develop high levels of erythropoietin. It causes a problem known together polycythaemia which method high red blood cabinet count. In plenty of people, polycythaemia does no cause any kind of symptoms. However, there are some general and also non-specific symptoms including weakness, fatigue, headache, itching, joint pain and also dizziness.

What happens if I have too small erythropoietin?

If you have too small erythropoietin, i beg your pardon is usually resulted in by chronic kidney disease, there will certainly be under red blood cells and also you will have anaemia. Erythropoietin has actually been made synthetically because that the treatment of anaemia that outcomes from chronic kidney failure. That is also given to patients through some rarer varieties of cancer.Some experienced athletes have used this kind of erythropoietin (known as blood doping) to improve their performance, particularly to boost endurance. Artificially boosting your erythropoietin level produces an ext haemoglobin and also red blood cells and therefore enhances the amount of oxygen that deserve to be ceded to tissues, specifically muscles. This deserve to improve performance capacity, although this kind of doping exercise is prohibition by most experienced sport committees.

Can we measure erythropoietin in the blood?

Yes, erythropoietin hormone levels deserve to be measured in the blood. The test is done v a an easy blood test, best a morning sample collection. A needle is offered for drawing blood indigenous a vein on your arm. You don’t need any type of special preparations prior to a blood test, however you have to let your health care provider know if you are taking any kind of medications, vitamin additional or any type of illicit drugs or herbs.

The test Results

The test results may vary based upon your age, sex, health status, and also even the method used because that the test. Your medical care provider will talk about your results with you.

Too tiny erythropoietin could be due to anaemia (low red blood cells), specifically anaemia due to kidney disease. Raised levels the erythropoietin could be because of a condition called polycythaemia (too numerous red blood cells) or it might be evidence of a kidney tumour.

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EPO doping in Athletes

Raised level of Erythropoietin in athletes indicate erythropoietin abuse (doping). EPO doping can boost the number of red blood cells and there by increased accessibility of oxygen come the muscles. This can help the athlete with boosted performance ability and endurance. Blood doping is illegal specifically in experienced sports. Expert athletes room asked to take this test to find out if they room violating the anti-doping law.