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Usual Diluents

Standard Dilutions
<0 to 1 gram> <50 ml> <30 min>< end 1 gram> <100 ml> <30 min>

Stability / Miscellaneous

Label: Refrigerate. Complete daily dose have to not exceed 4 grams.

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Stability data:

DrugStabilityRefrigeratedStabilityRoom Temp.ReconstitutedVial/PowderNotes
Ceftriaxone Powder10 work Refrigerated (4°C)Sterile powder must be stored in ~ 20° come 25°C (68° come 77°F) and also protected indigenous light. After ~ reconstitution, defense from regular light is no necessary.

2 job Room Temp. (25°C)

Powder The shade of solutions arrays from irradiate yellow come amber, depending on the size of storage, concentration and diluent used.
Ceftriaxone SolutionStore in a freezer qualified of maintaining a temperature of -20°C/-4°F.

The thawed systems is steady for 21 work under refrigeration (5°C/41°F). Carry out not refreeze thawed antibiotics.

The thawed equipment is secure for 48 hrs at room temperature (25°C/77°F). Do not refreeze s antibiotics.SolutionCheck for minute leaks by squeezing container firmly. If leaks are detected, discard solution as sterility may be impaired.

IM injection preparation:250 mg/ 0.9 ml;500mg/ 1.8 ml;1 gram/3.6 ml;2grams/ 4.2 or 7.2 ml(H20; BS-H20; 0.5 come 1% lidocaine)

Usual dose: 1-2g ivpb q24h. Severe: 2g ivpb q12h.

No dosage adjustments forced in renal failure.PD: 750mg ivpb q12h--------------------------------------------------------------------------------INDICATIONS and USAGEBefore setting up treatment v ceftriaxone, appropriate specimens have to be acquired for isolation of the causative organism and also for determination of that is susceptibility to the drug. Therapy may be instituted before obtaining outcomes of susceptibility testing. To minimize the advancement of drug-resistant bacteria and maintain the performance of ceftriaxone and also other antibacterial drugs, ceftriaxone have to be offered only to treat or avoid infections that room proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility info are available, they need to be thought about in picking or editing antibacterial therapy. In the absence of together data, local epidemiology and also susceptibility patterns may contribute to the empiric selection of therapy.

Ceftriaxone because that injection is shown for the therapy of the adhering to infections when caused by prone organisms:

Lower respiratory Tract Infections resulted in by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis or Serratia marcescens.

Acute bacterial Otitis Media resulted in by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains) or Moraxella catarrhalis (including beta-lactamase creating strains).

Skin and also Skin structure Infections led to by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans team streptococci, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii*, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis* or Peptostreptococcus species.

Urinary tract Infections (complicated and also uncomplicated) brought about by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii or Klebsiella pneumoniae.

Uncomplicated Gonorrhea (cervical/urethral and rectal) caused by Neisseria gonorrhoeae, including both penicillinase- and also nonpenicillinase-producing strains, and also pharyngeal gonorrhea resulted in by nonpenicillinase-producing strains of Neisseria gonorrhoeae.

Pelvic inflammatory Disease caused by Neisseria gonorrhoeae. Ceftriaxone for injection, like various other cephalosporins, has actually no activity against Chlamydia trachomatis. Therefore, as soon as cephalosporins are used in the therapy of patients with pelvic inflammatory condition and Chlamydia trachomatis is just one of the suspected pathogens, suitable antichlamydial coverage need to be added.

Bacterial Septicemia resulted in by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae or Klebsiella pneumoniae.

Bone and Joint Infections resulted in by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae or Enterobacter species.

Intra-Abdominal Infections led to by Escherichia coli, Klebsiella pneumoniae, Bacteroides fragilis, Clostridium types (Note: many strains that Clostridium difficile space resistant) or Peptostreptococcus species.

Meningitis caused by Haemophilus influenzae, Neisseria meningitidis or Streptococcus pneumoniae. Ceftriaxone because that injection has likewise been used successfully in a minimal number of situations of meningitis and also shunt infection brought about by Staphylococcus epidermidis* and Escherichia coli.**Efficacy for this organism in this organ system was learned in fewer than ten infections.

Surgical Prophylaxis: The preoperative administration of a single 1 gm sheep of ceftriaxone for injection may reduce the incidence that postoperative infections in patient undergoing surgical steps classified together contaminated or possibly contaminated (e.g., quality or ab hysterectomy or cholecystectomy for chronic calculous cholecystitis in high-risk patients, such as those end 70 years of age, with acute cholecystitis not requiring therapeutic antimicrobials, obstructive jaundice or common duct bile stones) and also in surgical patients for whom epidemic at the operative website would existing serious danger (e.g., throughout coronary artery bypass surgery). Although ceftriaxone because that injection has actually been displayed to have actually been as reliable as cefazolin in the prevention of infection complying with coronary artery bypass surgery, no placebo-controlled trials have actually been carried out to evaluate any cephalosporin antibiotic in the prevention of infection complying with coronary artery bypass surgery.

When administered prior to surgical procedures for which it is indicated, a solitary 1 gm sheep of ceftriaxone because that injection offers protection from many infections as result of susceptible organisms throughout the food of the procedure.

DOSAGE and also ADMINISTRATIONRocephin might be administered intravenously or intramuscularly.

Do not usage diluents containing calcium, such together Ringer’s systems or Hartmann’s solution, come reconstitute Rocephin. Particulate formation can result. Rocephin and also calcium-containing solutions, including continuous calcium-containing infusions such together parenteral nutrition, have to not be mixed or co-administered to any patient regardless of of age, even via different infusion present at different sites.

NEONATESHyperbilirubinemic neonates, specifically prematures, have to not be treated through Rocephin (see package insert because that CONTRAINDICATIONS).

PEDIATRIC PATIENTSFor the treatment of skin and skin framework infections, the recommended complete daily dose is 50 come 75 mg/kg provided once a day (or in equally split doses double a day). The full daily dose must not exceed 2 grams.

For the treatment of acute bacter otitis media, a single intramuscular sheep of 50 mg/kg (not come exceed 1 gram) is encourage (see INDICATIONS and also USAGE).

For the treatment of serious assorted infections other than meningitis, the recommended full daily sheep is 50 to 75 mg/kg, provided in divided doses every 12 hours. The complete daily dose must not exceed 2 grams.

In the treatment of meningitis, that is recommended that the early stage therapeutic sheep be 100 mg/kg (not to exceed 4 grams). Thereafter, a total daily sheep of 100 mg/kg/day (not come exceed 4 grams daily) is recommended. The day-to-day dose may be administered when a work (or in equally divided doses every 12 hours). The usual duration of treatment is 7 to 14 days.

ADULTSThe normal adult day-to-day dose is 1 come 2 grams provided once a job (or in equally separated doses twice a day) relying on the form and severity the infection. The full daily dose need to not exceed 4 grams.

If Chlamydia trachomatis is a suspected pathogen, appropriate antichlamydial coverage need to be added, because ceftriaxone sodium has actually no activity against this organism.

For the therapy of uncomplicated gonococcal infections, a single intramuscular sheep of 250 mg is recommended.

For preoperative usage (surgical prophylaxis), a single dose that 1 gram administered intravenously 1/2 to 2 hours prior to surgery is recommended.

Generally, Rocephin therapy need to be ongoing for at the very least 2 work after the signs and symptoms of infection have disappeared. The normal duration of treatment is 4 come 14 days; in complex infections, longer therapy might be required.

When dealing with infections resulted in by Streptococcus pyogenes, therapy need to be ongoing for at least 10 days.

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No dosage adjustment is crucial for patient with handicap of renal or hepatic function; however, blood levels must be monitored in patients with severe renal impairment (eg, dialysis patients) and in patients through both renal and hepatic dysfunctions.