Rumors the ranitidine reasons false positives for meth in drug screening have actually circulated for years, yet the conditions under i m sorry this would occur are extremely rare.

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Published7 February 2018

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Zantac (ranitidine) or comparable acid reflux medications cause users come falsely test positive for meth use.
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What"s TrueStudies the a currently discontinued urine experimentation protocol for amphetamines did present that, under rarely and particular circumstances, false positives might be caused by the mountain reflux medicine Zantac (ranitidine); over there is, together well, limited evidence of similar false positives using one check still ~ above the market, yet the occurrence is rare and likewise subject to particular conditions.


What"s False

Zantac, ranitidine, or various other related drugs consistently cause false positives on medicine tests.


In 2016, a case that usage of the over-the-counter acid reflux medicine Zantac (ranitidine) had produced a false positive result for methamphetamines showed up on social media; that claim resurfaced again in 2018.

As a followup come this report, researchers performed a somewhat larger-scale study in 1991 to investigate the possibility of false positives. Castle concluded that, when possible, it required extremely details circumstance:

We have shown that ranitidine can offer a positive result with the monoclonal EMIT d.a.u, assay, however this occurs just with high to pee levels present in a small percentage of patients within a short duration of time after a ranitidine dose.

Beckman Coulter AMPH assay is still vulnerable to far-reaching interference v ranitidine, presumably due to antibody cross-reactivity, whereas the Siemens EMIT II plus assay is free from such interference.

The feasible mechanism because that false positives, in both cases, is not the chemistry similarity that Zantac to amphetamines, however through the existence of unintended reactions in between Zantac and the chemicals supposed to interact with amphetamines, a trouble known together cross-reactivity, i m sorry is defined in a 2004 review on the topic:

Substances that change the measurable concentration of the analyte in the sample or change antibody binding have the right to potentially an outcome in assay interference. Analytical interference is characterized as the result of a substance present in the sample that changes the correct value of the result.

With this details in mind, we rate the insurance claim that Zantac reasons false positives for methamphetamine a mixture because, when there remains a opportunity that at the very least one check on the market might conceivably develop a false optimistic for amphetamines native Zantac, the problems that call for such a an outcome are rare and also most tests do not endure from this potential problem. Additionally, the test that produced the many attention in terms of potential false positives is no longer in consistent use.


Grinstead, Gregory F. “Ranitidine and also High concentration ofPhenylpropanolamlne Cross reaction in the EMIT Monoclonal Amphetamine/Methamphetamine Assay.” Clinical Chemistry. September 1989.


Poklis, Alphonse, et al. “Ranitidine Interference with the Monoclonal EMIT d.a.u.Amphetamin ethamphetamine Immunoassay.” Journal of analytical Toxicology. March 1991.


Liu, L., et al. “Ranitidine Interference with Standard Amphetamine Immunoassay.” Clinical Chimica Acta. 19 September 2015.

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Tate, Jill, and also Ward, Gred. “Interferences in Immunoassay.” The Clinical Biochemist Reviews. May 2004.